Prognostic Value Of The Pretreatment Ratio Of Albumin To Alkaline Phosphatase In Patients With Oral Cavity Carcinoma
Abstract
Objective: This study aimed to assess the prognostic value of the pretreatment albumin-to-alkaline phosphatase ratio (AAPR) regarding survival outcomes in patients with oral squamous cell carcinoma (OSCC) at all stages.
Meterial and Methods: We retrospectively reviewed patients with OSCC who underwent complete treatment between 2008 and 2018. The primary outcome was the ability of pretreatment AAPR to predict the 5-year overall survival (OS) and disease-free survival (DFS) rates, along with other clinical characteristics established for individualized survival prediction.
Results: A total of 327 patients were enrolled in this study. OS and DFS rates were 84.76% and 55.33%, respectively. The optimal cut-off value of pretreatment AAPR to predict OS was 0.52, with no significant difference compared to those with values less than 0.52 (OS: 86.32% vs. 81.03%, p-value=0.275; DFS: 55.18% vs. 55.65%, p-value=0.539, respectively). In both univariate and multivariate analyses using Cox proportional hazard models, advanced age (≥65 years) and the presence of extranodal extension were independent predictors of worse OS (HR: 4.02, 95% CI: 1.87, 8.65, p-value<0.001; HR: 3.83, 95% CI: 1.47, 9.98, p-value=0.014, respectively) and DFS (HR: 3.52, 95% CI: 1.66, 7.46, p-value<0.01; HR: 3.61, 95% CI: 1.42, 9.22, p-value=0.014, respectively).
Conclusion: Pretreatment AAPR was not an independent prognostic factor for OS and DFS in patients with all stages of OSCC. Advanced age and extranodal extension were associated with unfavorable OS and DFS.
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